A Methyl-Deficient Diet Modifies Early B Cell Development

1404 T Cell Development in B Cell - Deficient Mice

The cellular interactions in the anti-p-azobenzenearsonate (ABA) 1 suppressor T cell pathway, for the inhibition of ABA-specific delayed-type hypersensitivity and cytotoxic T cell responses, are restricted by Igh-linked genes (reviewed in 1). The inducer, Ts-1 (T suppressor cell), and the effector, Ts-3, suppressor T cells, and one of their factors (TsF1) bear the major crossreactive idiotypic ...

Methyl deficient diet aggravates experimental colitis in rats

Inflammatory bowel diseases (IBD) result from complex interactions between environmental and genetic factors. Low blood levels of vitamin B12 and folate and genetic variants of related target enzymes are associated with IBD risk, in population studies. To investigate the underlying mechanisms, we evaluated the effects of a methyl-deficient diet (MDD, folate, vitamin B12 and choline) in an exper...

Impaired T- and B-cell development in Tcl1-deficient mice.

TCL1, the overexpression of which may result in T-cell leukemia, is normally expressed in early embryonic tissues, the ovary, and lymphoid lineage cells. Our analysis of mouse B-lineage cells indicates that Tcl1 expression is initiated in pro-B cells and persists in splenic marginal zone and follicular B cells. T-lineage Tcl1 expression begins in thymocyte progenitors, continues in CD4(+)CD8(+)...

Development Lymphoid Kinase Promoter in Early B Cell Early B Cell

Early lifetime zinc supplementation protects zinc-deficient diet-induced alterations.

Preclinical and clinical data indicate the involvement of zinc in the pathophysiology and therapy of depression. A relationship between zinc-deficiency and depression symptoms was recently proposed. The present study investigated alterations in spontaneous locomotor activity and zinc concentrations in the serum, hippocampus and frontal cortex; these alterations were induced by subjecting rats t...